Which is best pantoprazole or omeprazole

Pantoprazole and omeprazole are both effective for GERD and erosive esophagitis. One PPI drug may be preferred over the other depending on the condition being treated and the cost of the medication. Pantoprazole and omeprazole are not recommended in pregnant women due to the risk of fetal harm.

However, in some cases, the benefits may outweigh the risk. Consult a doctor if you are pregnant. Consuming alcohol may increase certain side effects associated with pantoprazole or omeprazole.

Alcohol may worsen PPI side effects, such as headache and nausea. Over-the-counter OTC omeprazole contains the same active ingredient found in prescription-strength omeprazole. This treatment course should not be taken more than once every 4 months. Since pantoprazole and omeprazole work in identical ways, they should not be taken at the same time. They both work as PPIs to reduce the production of acid in the stomach. Taking them together could increase the risk of adverse effects.

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Type your drug name. What is the generic name? What is the brand name? Pantoprazole Protonix. Omeprazole Prilosec. Rilpivirine Nelfinavir Atazanavir Saquinavir Ritonavir. Mycophenolate mofetil Tacrolimus. Ketoconazole Itraconazole Voriconazole. Erlotinib Dasatinib Nilotinib. Ferrous fumarate Ferrous gluconate Ferrous sulfate Ferrous succinate. Diazepam Midazolam.

Clarithromycin Rifampin. Bob : It is a meta-analysis of 41 studies comparing various PPIs. The authors identified 20 studies of GERD, nine studies of peptic ulcer disease, and 16 studies of Helicobacter pylori therapy. Two studies of esomeprazole Nexium 40 mg versus omeprazole 20 mg found a small difference. The six remaining studies were a hodge-podge group of trials comparing various PPIs at different doses, none of which demonstrated any superiority.

Andrea : All of the studies, except for the two that compared esomeprazole and omeprazole, found that there were no differences among any of the drugs in the treatment of GERD. As for the two studies that suggested esomeprazole was better than omeprazole, the studies were not fair comparisons.

Both studies used higher dosages of esomperazole compared with omeprazole. This cannot be considered a true comparison of effectiveness.

In the study comparing esomeprazole with omeprazole, esomeprazole did better. Well, that's no surprise—esomeprazole is the active isomer of omeprazole, and the study authors used a dosage four times that of omeprazole.

Breaking this down, they used 40 mg of active drug esomeprazole versus 10 mg of active drug omeprazole the dosage is actually 20 mg, but since omeprazole is a racemic mixture, that is only 10 mg of active drug , and guess what? The drug not going off patent did better! And who sponsored the study? Astra-Zeneca, the manufacturer. Bob : I knew you would jump on the inappropriate comparison of esomeprazole with omeprazole. Another problem with this comparison is that a true clinical end point is not being measured.

But I have the same complaints as I did with the GERD studies regarding the use of unequal dosages and using endoscopic cure rates as the end point.

And do I even have to do the H. Sixteen studies with no differences noted among any PPIs. Bob : Meta-analysis can be tricky. A series of principles needs to be followed for the results to be valid.

In this study, the authors appropriately identified a clear study question, performed a fairly comprehensive review of available databases although they did not include any abstracts from presentations at symposia or obtain unpublished clinical trials from the FDA or the drug companies , and used clear end points to determine cure or failure—so far, so good. The most obvious faux pas the authors made was not grading the quality of the studies they incorporated in this meta-analysis.

They did, however, redeem them-selves slightly by incorporating only randomized prospective trials. Mark : This faux pas is a problem. How do we know that the studies they included were any good? We don't. I like their conclusions and I am sure they are correct, but they need to grade the papers included in their analysis; other-wise, we have no assurance that they were any good.

Bob : I feel comfortable saying there are no differences in efficacy among any PPIs for the above conditions. It also has been suggested that PPIs are associated with increased rates of community-acquired pneumonia 1 and Clostridium difficile colitis. Both drugs are typically covered by Medicare and most health insurance plans, although costs vary depending on your insurance provider.

Approved in , omeprazole was one of the first PPIs developed to treat conditions caused or made worse by high levels of stomach acid FDA, It was a major breakthrough at the time, and even 30 years later, research has found that PPIs are much better at suppressing acid formation in the stomach compared to H2 blockers like brand names Pepcid AC or Zantac Strand, Omeprazole is available as a delayed-release capsule or dissolvable powder and comes in amounts of 10 mg, 20 mg, 40 mg, and 60 mg.

Taken once daily, the effects of omeprazole kick in within an hour and can take up to four days to reach full effect Covis, Omeprazole treats a variety of conditions, but here are some of its main uses FDA, :.

Generally, omeprazole is safe and well-tolerated by patients. Side effects vary, but the most common ones include headache, abdominal pain, nausea, vomiting, diarrhea, and gas DailyMed, n. Less common side effects that have been reported by patients include back pain, change in sense of taste, and dizziness DailyMed, n. While rare, omeprazole may cause serious side effects like chronic kidney disease, pancreatitis, and liver damage Kinoshita, Serious or less common side effects — like bone fractures or chronic stomach inflammation — may be triggered in patients living with other underlying health conditions Thong, There is a long list of medications omeprazole may interact with , but listed here are the most serious ones FDA, :.

Consult with your healthcare provider first before taking this drug — especially if you have other health conditions or are taking multiple medications. Pantoprazole comes in time-released capsules or an oral suspension for those with difficulty swallowing pills.

For adults, a typical dosage is 40 mg once daily for up to 8 weeks FDA, Pantoprazole is also sometimes used off-label meaning used for indications not specifically approved by the FDA to treat H. The side effects of pantoprazole are similar to other PPIs, such as omeprazole. The most common side effects include nausea, diarrhea, vomiting, gas, and joint pain Makunts, Serious side effects are rare and may result from an allergy or drug sensitivity — contact a health provider right away if you experience a rash, swelling in your face, difficulty breathing, or throat tightness Casciaro, Long-term use of pantoprazole may also be linked to a higher risk of kidney problems.

While rare, other adverse reactions like bone fractures and memory loss have also been linked to long-term use of PPIs Makunts, So far, studies have found pantoprazole to have fewer drug interactions compared to omeprazole Wedemeyer,